STK4 Antikörper (pThr183)

Produktnummer ABIN7138786

Dieser Anti-STK4 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von STK4 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für STK4 Antikörper (pThr183) (ABIN7138786)

Target: STK4 (serine/threonine Kinase 4 (STK4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-STK4 Antikörper

Bindungsspezifität: pThr183

Verwendungszweck: Phospho-STK4 (Thr183) Antibody

Kreuzreaktivität: Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Andere Bezeichnung: STK4

Hintergrund:

Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.

Aliases: Kinase responsive to stress antibody, Krs2 antibody, Mammalian STE20 like protein kinase 1 antibody, Mammalian STE20-like protein kinase 1 antibody, Mammalian sterile 20 like 1 antibody, MST-1 antibody, MST1 antibody, Serine/threonine kinase 4 antibody, Serine/threonine protein kinase Krs 2 antibody, Serine/threonine-protein kinase 4 antibody, Serine/threonine-protein kinase Krs-2 antibody, STE20 like kinase MST1 antibody, STE20-like kinase MST1 antibody, STK4 antibody, STK4_HUMAN antibody, TIIAC antibody, YSK3 antibody

UniProt: Q13043

Pathways: Tube Formation